After testing the effects of a Mapk9 (Jnk2) knockout on acetaminophen-induced liver injury using C57BL/6J as wild type controls, the results were contrary to expectations.

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C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis.

2015年4月22日 · For spontaneously or targeted mutant mice, this notation makes perfect sense: “+” indicates the wildtype allele, and “-” the mutant allele. Thus, we designate our mouse …

If a mutation is maintained on either a mixed or segregating genetic background, wild-type mice (phenotypically non–mutant mice) from the colony are the best controls.

Research Associate Priscilla Lane calls the C57BL/6J "the mouse of choice" because not only is it a good breeder and long lived but it also has a low susceptibility to tumors and few unfavorable phenotypes.

An essential step in mouse breeding is genotyping your mice to ensure that they have the expected genotype. The genotype for a specified gene in a mouse can be homozygous, heterozygous, wild type, and sometimes hemizygous (such as X-linked genes or transgenes).

2021年3月17日 · So that model wild type mice are not a great model for predicting human antibody PK. So in Derry Roopenian's lab, we generated two transgenics the Tg 32, which in the mice, they lack mouse, FcRn and the transgene is driven by …

Delve into our comprehensive pricing details, meticulously curated to reflect the value and quality synonymous with JAX. Prices for JAX® Mice are included on each strain's datasheet under the “Pricing” tab.

001800 FVB/NJ FVB/NJ are a widely used multipurpose inbred strain. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ are commonly used for transgenic injection. FVB/NJ mice are homozygous for the retinal degeneration 1 allele of <em>Pde6b^rd1</em>, resulting in blindness by wean age.