The SOS response is a global response to DNA damage in which the cell cycle is arrested and DNA repair and mutagenesis are induced. The system involves the RecA protein (Rad51 in eukaryotes).

The SOS response allows the cell to survive sudden increases in DNA damage by inducing the expression of multiple factors that serve to promote the integrity of DNA. It is therefore a very important system that needs to be regulated at a large number of different levels.

The SOS response is a cellular mechanism induced by agents that threaten DNA integrity in prokaryotes that aids cell survival under stressful situations, since an unrepaired DNA damage may lead to deleterious mutations or even cell death. Cells are constantly exposed to environments that may contain DNA-damaging agents.

SOS repair refers to the DNA repair system, which uses RecA regulatory protein to inhibit the repressor’s activity and activate the SOS inducer genes to recover the DNA damage. It stands for “ Save Our Soul ”. The SOS system remains repressed until the conversion of RecA protein into RecA protease.

The SOS response is a cellular mechanism that is activated in response to DNA damage, such as that caused by radiation or toxins. It involves the expression of specific genes that are involved in DNA repair and can increase the mutation rate in the process.

The gram-negative bacterium Escherichia coli activates a transcriptional circuit, known as the SOS response following DNA damage or replicative stress. The SOS response has two key antagonistic regulatory proteins, LexA (negative) and RecA, (positive) that …

gens and the role of inducible DNA polymerase. The discovery of the SOS response system evolved from studies on the effect of UV irra-diation on Escherichia coli and consideration of seemingly unconnected data. It was ob-served that reactivation and mutagenesis of …

The SOS response and its behavior: more than just repair. The bacterial SOS response is a beautifully orchestrated response to DNA damage and is triggered by the sensing of long-lived single-stranded DNA (ssDNA).

2020年8月3日 · Recent studies have revealed that the SOS response plays significant roles beyond DNA damage repair. The goal of this review is to provide an overview of the SOS response in relation to persisters, tolerance, and shielding, …

2005年7月12日 · The bacterial SOS response kicks in when bacteria experience DNA damage, and helps the organisms correct and survive DNA damage events. This primer provides a foundation for understanding these events.