Mesangial cells are specialised cells in the kidney that make up the mesangium of the glomerulus. Together with the mesangial matrix, they form the vascular pole of the renal corpuscle. [1] The mesangial cell population accounts for approximately 30-40% of …

2021年9月10日 · Here, we review our current understanding of mesenchymal stromal cells and discuss how it informs the function of mesangial cells and their role in disease.

Mesangial cells are the phagocytic cells found in the mesangium of the glomerulus of the kidney, thought to aid in cleaning the filtration apparatus (Dorland, 2011).

Mesangial cells are specialized glomerular cells with smooth muscle cell characteristics that form the vascular pole of the glomerulus and remove residues and debris from the glomerular basement membrane. From: Clinical Immunology, 2020

The mesangial cells are the central hub connecting and supporting all these structures. The components as a unit ensure a high permselectivity hindering large plasma proteins from passing into the urine while readily filtering water and small solutes.

Intraglomerular mesangial cells aid neutrophils in removing other mesangial cells undergoing apoptosis, and other debris. Intraglomerular mesangial cells monitor capillary lumen glucose concentration via processes sent into the capillary lumen.

Insights into the molecular phenotype of kidney mesangial cells suggest that they are a specialized stromal cell of the glomerulus. Here, we review our current understanding of mesenchymal...

The paramount importance of mesangial cells for the formation of the glomerular capillary tuft has been established through mouse genetic models lacking mesangial progenitor cell ingress or mesangial proliferation.

Insights into the molecular phenotype of kidney mesangial cells suggest that they are a specialized stromal cell of the glomerulus. Here, we review our current understanding of mesenchymal stromal cells and discuss how it informs the …

Mesangial cells are specialized cells found within the glomerular tuft of the kidney's nephrons. They play a crucial role in maintaining the structural and functional integrity of the glomerular filtration barrier, which is essential for the kidney's ability to filter blood and produce urine.