2021年10月22日 · The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases, including cancer, as a result of genetic ...

Mitogen-activated protein kinase (MAPK) modules containing three sequentially activated protein kinases are key components of a series of vital signal transduction pathways that regulate processes such as cell proliferation, cell differentiation, and cell death in eukaryotes from yeast to humans (Qi and Elion 2005; Raman et al. 2007; Keshet and ...

2002年3月1日 · MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis.

Mitogen-activated protein kinase (MAPK) pathways are implicated in several cellular processes including proliferation, differentiation, apoptosis, cell survival, cell motility, metabolism, stress response and inflammation. MAPK pathways transmit and ...

2011年9月1日 · The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response.

The MAPK signaling pathway is essential in regulating many cellular processes including inflammation, cell stress response, cell differentiation, cell division, cell proliferation, metabolism, motility and apoptosis.

2008年3月18日 · In this review we present some background on MAPK pathways and then discuss key findings that suggest mechanisms that may link MAPKs to specific diseases.

2019年10月22日 · The present paper discusses new insights into MAPK as a complex cell signaling pathway with roles in the sustenance of cellular normal conduit, response to cancer therapy, and activation of compensatory pathways.

Mitogen-activated protein kinase (MAPK) is a serine/threonine protein kinase that is closely related to cell growth and inflammation. The MAPK family mainly consists of three members: extracellular signal-regulated kinase (ERK), stress-activated protein kinase/Jun N-terminal-kinase (SAPK/JNK) and p38 [104].

The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.