Lipoprotein lipase (LPL) (EC 3.1.1.34, systematic name triacylglycerol acylhydrolase (lipoprotein-dependent)) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase.

2023年7月30日 · Lipoprotein lipase (LPL) is an extracellular enzyme on the vascular endothelial surface that degrades circulating triglycerides in the bloodstream. These triglycerides are embedded in very low-density lipoproteins (VLDL) and …

2024年12月10日 · Lipoprotein lipase (LPL) deficiency is a genetic disorder inherited in an autosomal recessive pattern, typically presenting in childhood. This disorder is characterized by severe hypertriglyceridemia and chylomicronemia and is the most common form of chylomicronemia.

Lipoprotein lipase (LPL) is one of the most important factors in systemic lipid partitioning and metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such as chylomicrons and VLDL.

Lipoprotein lipase (LPL) catalyses the hydrolysis of the triacylglycerol component of circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified fatty acids and 2-monoacylglycerol for tissue utilisation.

Lipoprotein lipase breaks down triglycerides carried by two different types of lipoproteins, which bring fat to the bloodstream from different organs. Fat from the intestine, which is taken in from the diet, is transported to the bloodstream by lipoproteins called chylomicrons.

2002年10月1日 · Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed.

Lipoprotein lipase (LpL) is well known for its lipolytic action in blood lipoprotein triglyceride catabolism. This article summarizes the recent mechanistic and molecular studies on elucidating the “unconventional” roles of LpL in mediating biological events related to immune cell response and lipid transport in the pathogenesis of ...

Lipoprotein lipase (LpL)-mediated lipolysis has long been known to be the rate-limiting step in the removal of triglyceride from the blood stream. Within the past decade, LpL and its regulators have garnered increased attention in part because genes that modulate LpL activity correlate with the risk of cardiovascular disease (CVD) events.

Lipoprotein lipase (LPL) is a central enzyme in overall lipid transport and metabolism, and plays a crucial role in human lipid homeostasis and energy balance. It is mainly synthesized by parenchymal cells in adipose, skeletal and cardiac muscle.