In Vitro and In Vivo Antimicrobial Activity of Hypochlorous Acid ...
网页2022年10月3日 · Daptomycin plus HClO lock therapy showed the highest activity for experimental CRI with S. epidermidis. HClO could be an effective strategy for treating infections caused by extensively drug-resistant or multidrug-resistant and biofilm-producing strains in medical devices and chronic wounds.
The inhibition of bacterial growth by hypochlorous acid. Possible …
网页2001年1月1日 · Neutrophils deficient in myeloperoxidase cannot convert H2O2 to HOCl, yet can kill bacteria. We have found that H2O2 is only 6% as effective as HOCl in inhibiting E. coli growth and cell division (0.34 mM-H2O2 required for 50% inhibition of colony formation), and taurine or amino acids do not block this effect.
Evaluating the bactericidal action of hypochlorous acid in …
网页2020年11月1日 · Our results showed that more reagent HOCl was required to kill bacteria in culture media than in aqueous buffer, and this corresponded to the lower concentration of reactive chlorine species achieved in the media.
Antimicrobial efficacy, mode of action and in vivo use of …
网页2023年3月27日 · Aqueous solutions of HOCl, even in trace amounts, will kill most pathogens within 30 seconds of exposure. Additional actions of HOCl include reduction of mast cell degranulation and active capillary dilation.
In vitro cytotoxicity and antibacterial activity of hypochlorous acid ...
网页2024年1月1日 · Five different concentrations (100, 200, 300, 400, and 500 ppm) of HOCl were evaluated for their antimicrobial efficacy against Gram-negative (A. actinomycetcmcomitans and P. gingivalis) and Gram-positive bacteria (S. mutans and S. sanguinis) after treatment for 1 and 10 min. Sodium hypochlorite (NaOCl) and chlorhexidine (CHX) were used as ...
In Vitro and In Vivo Antimicrobial Activity of Hypochlorous Acid ...
网页First, we determined the antimicrobial efficacy of hypochlorous acid (HClO) against bacterial, fungal, and yeast strains growing planktonically and growing in biofilms. Second, we sought to compare the activity of the combination of daptomycin and HClO versus ….
Antimicrobial action and cytotoxicity of hypochlorous acid …
网页2024年7月1日 · HClO obtained from the electrolytic device at both concentrations showed lower cytotoxicity when compared to NaOCl and CHX in this study. This result rejects the second null hypothesis of present study, being in accordance with some findings in literature, where NaOCl and CHX revealed undesirable effects regarding cytotoxicity ( Gatot et al ...
The effects of neutrophil-generated hypochlorous acid and …
网页HOCl is a strong inducer of protein aggregation, which bacteria can counteract by chaperone-like holdases that bind unfolding proteins without the need for energy in the form of ATP.
Surviving Reactive Chlorine Stress: Responses of Gram-Negative
网页2020年8月11日 · Among the most widespread oxidizing agents, reactive oxygen species (ROS), such as hydrogen peroxide, and reactive chlorine species (RCS), such as hypochlorous acid, are the most abundant. Of these, NaOCl, which is more commonly known as household bleach, is the most used chlorine-based disinfectant [31].
How antibiotics kill bacteria: from targets to networks
网页2010年5月4日 · Bactericidal antibiotics target a diverse set of biomolecules for inhibition to achieve cell death, including DNA topoisomerases (involved in modulating DNA topology), RNA polymerase (involved...