Regulation and function of the mammalian tricarboxylic acid cycle
2022年12月26日 · By converting the glycolytic product pyruvate into a substrate for TCA cycle oxidation, the PDHC functions as a gatekeeping enzyme that links glycolysis to the TCA cycle and mitochondrial respiration. Glycolysis-derived pyruvate has alternative fates outside the mitochondrial oxidation.
Mitochondrial TCA cycle metabolites control physiology and …
2020年1月3日 · Recent evidence confers a new role for TCA cycle intermediates, generally thought to be important for biosynthetic purposes, as signaling molecules with functions controlling chromatin...
Respiratory metabolism: glycolysis, the TCA cycle and …
2004年6月1日 · The respiratory pathways of glycolysis, the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain are ubiquitous throughout nature. They are essential for both energy provision in heterotrophic cells and a wide range of other physiological functions.
Glycolysis - PMC - National Center for Biotechnology Information
In the presence of oxygen, glycolysis generates pyruvate, which enters the TCA cycle (also called the citric acid cycle and the Krebs cycle) located within mitochondria to produce ATP.
Respiratory metabolism: glycolysis, the TCA cycle and ... - PubMed
The respiratory pathways of glycolysis, the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain are ubiquitous throughout nature. They are essential for both energy provision in heterotrophic cells and a wide range of other physiological functions.
Tricarboxylic Acid (TCA) Cycle – biochemistry
2022年10月28日 · The pyruvate produced through glycolysis is transported into the mitochondria, where it is oxidized to acetyl CoA, by action of pyruvate dehydrogenase, and then enters the TCA cycle. The PDH reaction is critical, as it is irreversible and ensures that acetyl-coA cannot be used in the reverse reaction for gluconeogenesis.
5.3: 5.3 The TCA Cycle - Biology LibreTexts
2022年12月30日 · Glycolysis in eukaryotes, as be ts its prokaryotic origins, happens in the cytoplasm. The TCA cycle (also called the citric acid cycle) happens inside the matrix of the mitochondria, a double-membraned organelle.
Glucose feeds the TCA cycle via circulating lactate | Nature
2017年10月18日 · Nearly complete lactate sharing between tissues effectively decouples glycolysis and the TCA cycle in individual tissues, allowing independent tissue-specific regulation of both processes.
Glycolysis - Reactions - Phases - Regulation - TeachMePhysiology
2024年4月8日 · Glycolysis is the metabolism of glucose into two pyruvate molecules, with the net generation of two molecules of ATP and two molecules of NADH. It is regulated at the entry to the pathway and at the irreversible steps (1, 3, and 10). This will be discussed in more detail below.
15.4: Regulation of Glycolysis - Biology LibreTexts
2024年5月22日 · There are three major enzymatic control points within the glycolytic pathway. These include hexokinase, phosphofructokinase, and pyruvate kinase reactions. Key drivers for regulating the pathway are energy demand: within the cell as determined by local indicators such as ATP and AMP.
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