Oct 31, 2017. #2. 22 short, 22 long and 22 long rifle can all be shot out of a 22 long rifle chamber, be it a rifle or a hand gun. Shorts and longs may not activate a semi auto. I used to by 22 shorts for $0.15 a box of fifty, longs for 0.25 and long rifle for 0.35. I …