2022年8月10日 · Ebola Virus are generally approximately 80 nm in diameter, 970 nm long. They are cylindrical/tubular, and contain viral envelope, matrix, and nucleocapsid components. The virus generally appears in a long, filamentous form, but it can also be “U-shaped,” in the shape of a “6” (the “shepherd’s crook” appearance), or even circular.

Ebola virus (EBOV), member of genus Ebolavirus, family Filoviridae, have a non-segmented, single-stranded RNA that contains seven genes: (a) nucleoprotein (NP), (b) viral protein 35 (VP35), (c) VP40, (d) glycoprotein (GP), (e) VP30, (f) VP24, and (g) RNA polymerase (L).

Ebolavirus is a filamentous, enveloped virus within the order Mononegavirales which also contains rabies and measles viruses. [15] . This order is characterized by non-segmented, single-stranded negative-sense RNA (-ssRNA) genomes that are surrounded by a helical nucleocapsid. [16] .

2012年2月27日 · Ebola virus is a highly pathogenic filovirus causing severe hemorrhagic fever with high mortality rates. It assembles heterogenous, filamentous, enveloped virus particles containing a negative-sense, single-stranded RNA genome packaged within a helical nucleocapsid (NC).

2024年10月21日 · Explore the intricate processes of Ebola virus structure, entry, replication, and its complex interactions with host cells. Ebola virus is a highly infectious pathogen responsible …

Ebolavirus (EBOV) is a highly virulent pathogen capable of causing a severe hemorrhagic fever with 50–90% lethality. The EBOV glycoprotein (GP) is the only virally expressed protein on the virion surface and is critical for attachment to host cells and catalysis of membrane fusion.

There have been no high-resolution reconstructions of complete mononegavirus NCs. Here, we have applied cryo-electron tomography and subtomogram averaging to determine the structure of Ebola virus NC within intact viruses and recombinant NC-like assemblies.

2022年9月28日 · Structural studies of the Ebola virus polymerase complex provide insights into its function and demonstrate the structural basis of its inhibition by suramin.

2022年2月8日 · It comprises of negative sense, single stranded RNA genome. Structural proteins associated with the nucleocapsid are the nucleoprotein (NP), VP30, VP35, and the polymerase (L) protein. Membrane-associated proteins are the matrix protein (VP40), VP24, and the GP (peplomer glycoprotein).

2017年11月8日 · Here we apply cryo-electron tomography and subtomogram averaging to determine the structure of Ebola virus nucleocapsid within intact viruses and recombinant nucleocapsid-like assemblies.