Cysteine - Wikipedia
Cysteinyl is a residue in high- protein foods. Some foods considered rich in cysteine include poultry, eggs, beef, and whole grains. In high-protein diets, cysteine may be partially responsible for reduced blood pressure and stroke risk. [ 13 ]
Cysteines and Disulfide Bonds as Structure-Forming Units: Insights …
2020年4月23日 · The formation of a disulfide bond by two side chain S γ atoms of spatially proximal cysteines constitutes a two-electron oxidation process leading from reduced sulfhydryl groups of cysteines (S-H) to the oxidized cystine (S-S) residue.
Cysteine Residue - an overview | ScienceDirect Topics
Cysteine residue is a specific amino acid component in proteins that contains a sulfur atom, making it a valuable target for simplifying protein analysis due to its high representation in human proteins and availability of chemistries for selective targeting.
Cysteine Reactivity Across the Sub-Cellular Universe.
Cysteine residues have evolved to exploit these unique subcellular conditions to generate functional diversity across the subcellular proteome. The pH and redox states of the various organelles that influence cysteine function are summarized below.
Functional Diversity of Cysteine Residues in Proteins and Unique ...
2008年9月9日 · We discuss different functional categories of cysteine residues, describe methods for discrimination between catalytic and noncatalytic and between redox and non-redox cysteine residues and highlight unique properties of the redox-active cysteines based on evolutionary conservation, secondary and three-dimensional structures, and sporadic ...
Proteome-wide analysis of cysteine oxidation reveals metabolic ... - Nature
2018年4月20日 · Reactive oxygen species (ROS) are increasingly recognised as important signalling molecules through oxidation of protein cysteine residues. Comprehensive identification of redox-regulated...
Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation
Thiol groups in protein cysteine (Cys) residues can undergo one- and two-electron oxidn. reactions leading to the formation of thiyl radicals or sulfenic acids, resp. In this mini-review we summarize the mechanisms and kinetics of the formation of …
A lysine–cysteine redox switch with an NOS bridge regulates ... - Nature
2021年5月5日 · Here we report the discovery of a covalent crosslink between a cysteine and a lysine residue with a NOS bridge that serves as an allosteric redox switch in the transaldolase enzyme of...
Mapping reactive cysteines | Nature Chemical Biology
2011年1月18日 · A new quantitative proteomic approach can identify reactive cysteine residues in native proteins and distinguish them on the basis of reactivity.
Cysteine reactivity across the subcellular universe - PubMed
The unique functions of cysteine residues found in the mitochondria and endoplasmic reticulum are highlighted, together with an overview into chemoproteomic platforms employed to investigate cysteine reactivity in subcellular organelles.