PTPRC - Wikipedia
网页CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. CD45 does not colocalize with lipid rafts on murine and human non-transformed hematopoietic cells, but CD45 positioning within lipid rafts is modified during their oncogenic transformation to acute myeloid leukemia.
CD45-T细胞守门人 - 知乎 - 知乎专栏
网页CD45是一种受体型蛋白酪氨酸磷酸酶，可积极调节T细胞抗原受体信号传导。研究认为二聚化抑制CD45活性，尽管CD45的调节配体仍然难以捉摸。Xu和Weiss对此提供了一个可能的解释。二聚化可以通过存在于细胞表面的CD45亚型来确定。
The role of CD45 and CD45-associated molecules in T cell activation
网页CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells. On T cells the extracellular domain of CD45 is expressed in several different isoforms, and the particular isoform(s) …
CD45 in human physiology and clinical medicine - PubMed
网页CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively expressed on all nucleated cells of the hematopoietic system. It is characterized by the expression of several isoforms, specific to a certain cell type and the developmental or activation status of the cell.
CD45 functions as a signaling gatekeeper in T cells - Science
网页2019年10月22日 · Thus, these findings suggest that CD45 regulates T cell activation by acting as a gatekeeper of antigen presentation, filtering out weak signals that could induce unnecessary, and potentially harmful, T cell–mediated immune responses.
Protein tyrosine phosphatase receptor type C (PTPRC or CD45)
网页2021年5月26日 · CD45 is an essential protein on the surface of cells of the haematological and immunological systems. It has been used as a diagnostic tool to identify cells of haematological origin, but its function and structure are not widely understood. This review aims to update information on CD45.
CD45 functions as a signaling gatekeeper in T cells - PubMed
网页2019年10月22日 · T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 activates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been …
CD45: A Critical Regulator of Signaling Thresholds in Immune Cells
网页Studies of CD45 mutant cell lines, CD45-deficient mice, and CD45-deficient humans initially demonstrated the essential role of CD45 in antigen receptor signal transduction and lymphocyte development. It is now known that CD45 also modulates signals emanating from integrin and cytokine receptors.
CD45: a critical regulator in immune cells to predict severe and …
网页2020年10月10日 · CD45 is a transmembrane phosphatase that functions in T cell activation and signaling. Multiple CD45 isoforms are simultaneously expressed on T cells due to alternative splicing of three exons that correspond to extracellular domains A, B, and C or the exclusion of all three (CD45RO).
Initiation of T cell signaling by CD45 segregation at 'close ... - Nature
网页2016年3月21日 · It has been proposed that the local segregation of kinases and the tyrosine phosphatase CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs and whether it...