Two terpenoids, vetivazulene (4,8-dimethyl-2-isopropylazulene) and guaiazulene (1,4-dimethyl-7-isopropylazulene), that feature the azulene skeleton are found in nature as constituents of pigments in mushrooms, guaiac wood oil, and some marine invertebrates.

Azulene derivatives occur naturally in mushrooms e.g., Lactarius indigo. Chamazulene can be found in camomile, wormwood, or achillea oil and is known for antiallergic, antibacterial, and anti-inflammatory applications. These compounds have also revealed themselves to have some cosmetic uses, especially in soothing creams and ointments [17].

Azulene is an aromatic hydrocarbon that possesses a unique chemical structure and interesting biological properties. Azulene derivatives, including guaiazulene or chamazulene, occur in nature as components of many plants and mushrooms, such as Matricaria chamomilla, Artemisia absinthium, Achillea millefolium, and Lactarius indigo. Due to ...

2021年4月1日 · Azulene is an aromatic hydrocarbon that possesses a unique chemical structure and interesting biological properties. Azulene derivatives, including guaiazulene or chamazulene, occur in nature...

2023年7月12日 · In this study, we investigated a fat-soluble azulene derivative isolated from the mushroom Lactarius indigo as a potential candidate for a natural blue colorant. We developed its first total synthesis, where the azulene skeleton was constructed from a pyridine derivative and an ethynyl group was converted into an isopropenyl group using ...

The structure of a new naturally-occurring azulene, 1-stearoyloxymethylene-4-methyl-7-isopropenylazulene, obtained from an acetone extract of the blue mushroom Lactarius indigo, has been determined by chemical and spectral methods. For reviews on naturally-occurring azulenes, see A.J. Haagen-Smith, Fortschr.

Azulene is an aromatic hydrocarbon that possesses a unique chemical structure and interesting biological properties. Azulene derivatives, including guaiazulene or chamazulene, occur in nature as components of many plants and mushrooms, such as Matricaria chamomilla, Artemisia absinthium Achillea millefolium, and Lactarius indigo.

Azulene and its derivatives demonstrate promising anti-inflammatory properties, which create new therapeutic perspectives in dermatology. Structural modifications of azulene can influence various biological effects such as stimulating the production of pro-inflammatory cytokines or immunostimulatory activity.

2021年1月30日 · Azulene derivatives occur naturally in mushrooms e.g., Lactarius indigo. Chamazulene can be found in camomile, wormwood, or achillea oil and is known for antiallergic, antibacterial, and anti-inflammatory applications.

2024年4月27日 · Azulene demonstrates the ability to exert anti-inflammatory effects through complex interactions with biological pathways. One of the key mechanisms involves the inhibition of the enzyme cyclooxygenase-2 (COX-2), which participates in the biosynthesis of prostaglandins, key mediators of inflammatory processes.