Mecillinam - Wikipedia
Mecillinam (INN) or amdinocillin (USAN) is an extended-spectrum penicillin antibiotic of the amidinopenicillin class that binds specifically to penicillin binding protein 2 (PBP2), [2] and is only considered to be active against Gram-negative bacteria. It is used primarily in the treatment of urinary tract infections, and has also been used to ...
美西林 - 维基百科，自由的百科全书
美西林（INN：Mecillinam；USAN：Amdinocillin）是一種广谱半合成青霉素 [2] ，對革兰氏阴性菌作用强，也可用來治療傷寒和副伤寒 [3] [4] 。 其口服利用率很差， 匹美西林 則是針對此缺陷開發出來的。
Pivmecillinam - Wikipedia
Pivmecillinam (INN), or amdinocillin pivoxil (USAN), sold under the brand name Selexid and Pivya among others, is an orally active prodrug of mecillinam, an extended-spectrum penicillin antibiotic. Pivmecillinam is the pivaloyloxymethyl ester of mecillinam. The most common side effects include nausea and diarrhea. [2]
Amdinocillin: Uses, Interactions, Mechanism of Action - DrugBank …
2005年6月13日 · Amdinocillin is a stong and specific antagonist of Penicillin Binding Protein-2 (PBP 2). It is active against gram negative bacteria, preventing cell wall synthesis by inhibiting the activity of PBP2.
美西林 - 百度百科
美西林为第三代广谱 半合成青霉素，是从半合成的脒基类半合成青霉素中找到的一种新的化合物，经酶水解而半合成的 氮卓脒青霉素。. 美西林为杀菌剂，是通过干扰 细菌细胞壁 的生物合成而起抗菌作用。. 美西林主要作用于细菌的转肽酶。. 美西林对 革兰 ...
Amdinocillin | C15H23N3O3S | CID 36273 - PubChem
Amdinocillin is a semisynthetic, broad spectrum beta-lactam penicillin with antibacterial activity. Amdinocillin specifically binds to and inactivates penicillin-binding protein 2 (PBP 2) located on the inner membrane of the bacterial cell wall.
Mecillinam (Amdinocillin) - 百度百科
Mecillinam (Amdinocillin)是一款对革兰阴性菌、 大肠杆菌 、志贺菌、沙门菌、 克雷白杆菌 、枸橼酸杆菌及部分沙雷杆菌等有良好的西药。. 本品对 革兰氏阳性菌 作用弱，对 革兰阴性菌 有较好抗菌作用，对 革兰氏阴性菌 ，包括 大肠杆菌 、志贺菌、沙门菌、 克雷白 ...
Three versus five days of pivmecillinam for community-acquired ...
2019年2月15日 · Pivmecillinam (amdinocillin pivoxil) is the oral pro-drug of the antimicrobially active mecillinam (amdinocillin), a unique narrow-spectrum beta-lactam antibiotic that is highly effective against the majority of Enterobacteriaceae, including Escherichia coli that is the most common pathogen to cause UTI .
Amdinocillin: a novel penicillin. Antibacterial activity, …
Amdinocillin is a novel penicillin whose antibacterial activity is derived from its ability to bind specifically and avidly to Penicillin Binding Protein-2 (PBP 2). Other beta-lactams bind almost exclusively to PBPs 1 and 3. This unique feature has prompted many …
NCATS Inxight Drugs — AMDINOCILLIN
Amdinocillin is a novel, semisynthetic penicillin effective against many gram-negative bacteria. The antibacterial activity of amdinocillin is derived from its ability to bind specifically and avidly to Penicillin Binding Protein-2 (PBP 2).