2015年4月29日 · Here we show that MUC2 mucin plays a dual functional role in the colon to stimulate β-defensin production in the presence of the proinflammatory cytokine interleukin-1β …

MUC1, MUC2, MUC3, and MUC4 are the predominant mucus detected in colorectum, with MUC2 being produced specifically in goblet cells (21, 24, 25). MUC2 exhibits similar structural and …

Here we show that MUC2 mucin plays a dual functional role in the colon to stimulate β-defensin production in the presence of the proinflammatory cytokine interleukin-1β (IL-1β) and …

2017年7月19日 · Downregulation of Mucin 2 (MUC2) expression is associated with early carcinogenesis events in colon cancer. MUC2 plays a role in the progression of colon cancer, …

2020年12月1日 · MUC2 mucin production impacts host survival by altering the total pathogenic and gut microbiota on the mucosal surface of the colon during the attaching and effacing of E. …

In the light of current literature, the present review explicates the regulation, functional mechanisms and essential role of MUC2 in colorectal cancer and aids in providing deep …

2010年6月25日 · These mucus layers are organized around the highly glycosylated MUC2 mucin, forming a large, net-like polymer that is secreted by the goblet cells. The inner mucus layer is …

These findings show that the Muc2 mucin can build a mucus barrier that separates bacteria from the colon epithelia and suggest that defects in this mucus can cause colon inflammation.

2019年2月27日 · In vivo, WFDC2 preserves the integrity of tight junctions between epithelial cells and prevents invasion by commensal bacteria and mucosal inflammation. We delineate …

2024年5月28日 · The MUC2 mucin protects the colonic epithelium by a two-layered mucus with an inner attached bacteria-free layer and an outer layer harboring commensal bacteria. CysD …