2024年6月10日 · The short answer: CRISPR can precisely modify a piece of DNA or its chemistry (so-called epigenetics) in the human body, making it a potential tool for clinical uses in the biomedical sciences.

2023年3月10日 · Last year, Verve Therapeutics started the first human trial of a CRISPR treatment that could benefit most people—a signal that gene editing may be ready to go mainstream.

2019年4月16日 · CRISPR is a new kind of genetic engineering that gives scientists the power to edit DNA much more easily than ever. Researchers think CRISPR could revolutionize how they prevent and treat many...

2023年3月9日 · CRISPR gene editing means a cure for sickle cell disease is on the horizon. However, the life-changing treatment is likely to remain out of reach for most of those who could benefit.

2022年1月4日 · In a landmark trial, a group of scientists from the U.K. and New Zealand showed that CRISPR can be used to successfully edit genes in the human body. Their work involved six patients with a devastating genetic disease called transthyretin amyloidosis, and was published in the New England Journal of Medicine in June.

We first introduce the CRISPR system and explain how it works as a gene editing tool. We then highlight current and potential clinical uses of CRISPR in areas such as genetic disorders, infectious diseases, cancer, and regenerative medicine.

This review aims to (1) provide a brief history of gene therapy prior to CRISPR and discuss its ethical dilemmas, (2) describe the mechanisms by which CRISPR/Cas9 induces gene edits, (3) discuss the current limitations and advancements made for CRISPR technology for therapeutic translation, and (4) highlight a few recent clinical trials ...

2020年8月25日 · In a study recently published in Nature Medicine, 1 Lu et al. examined the feasibility and safety of using CRISPR-engineered T cells to treat late-stage lung cancer. They demonstrated very low...

2019年8月6日 · Scientists can design CRISPR to act as molecular scissors to snip a cell’s DNA in specific, pre-determined locations — in this case around the aberrant CEP290 gene — and remove it. Without the...

In this review, an overview of the CRISPR-Cas systems will be introduced, including the innovations and applications in human disease research and gene therapy, as well as the challenges and opportunities that will be faced in the practical application of …