N-demethylation of 3° amines is by the von Braun reaction, which uses BrCN as the reagent to give the corresponding nor-derivatives. A modern variation of the von Braun reaction was developed, where BrCN was superseded by ethyl chloroformate.

2007年11月17日 · N-Demethylation is a key step in the preparation of a number of semisynthetic opiate pharmaceuticals. Herein we report a high-yielding, catalytic procedure for the N-demethylation of opiates which has a number of advantages over existing methods.

The removal of an N-methyl group, or N-demethylation, is a useful chemical transformation in organic synthesis which has particular importance in the field of alkaloid chemistry. Historically, tertiary N-methyl alkaloids have been N-demethylated using the same methods as for N-dealkylating tertiary amines.

2004年1月23日 · A traditional preparative chromatographic column can be used to achieve quantitative N-demethylation of tertiary N-methylamines and alkaloids. The filling is the crucial part and is loaded with different solid reagents in three reaction zones.

脱甲基化 （英語： Demethylation）是一种结果使得 甲基 （CH 3）从一个分子上脱下的化学反应 [1][2]。 最常见的脱甲基化方法是将氢原子置换掉甲基，结果也就是使得净损失一个碳原子与两个氢原子。 脱甲基化的对应物是 甲基化。 在 生物化学 系统中，脱甲基化的过程是被 脱甲基酶 催化 进行的。 这些酶氧化N- 甲基，发生在 组蛋白 和某些形式的DNA中： 一种这样的氧化酶家族是 细胞色素P450 [3]。 在 生物化学 体系中，此过程称为 脱甲基作用，常由 酶 催化：例如肝脏酶 …

2019年6月11日 · Thebaine is converted into painkillers and opiate addiction treatments, the latter requiring a chemical reaction called N-demethylation. Current opiate N-demethylation utilizes noxious reagents...

2011年6月1日 · The N-demethylation reaction could be initiated either by hydrogen atom transfer (HAT) or by the abstraction of an electron from the lone pair of the amine–N followed by subsequent quenching of the charge on the nitrogen by electron transfer from the carbon with concomitant loss of a proton from the methyl group (SET) [6].

2020年12月1日 · Glycine betaine monooxygenase, an unusual Rieske-type oxygenase system, catalyzes the oxidative N-demethylation of glycine betaine in chromohalobacter salexigens dsm 3043

2022年8月3日 · The demethylation of N,N-dimethylanilines promoted by diisopropyl azodicarboxylate (DIAD) to provide N-methylanilines was achieved in this paper. This protocol featured with mild reaction condition, simple operation and moderate to good yield.

2006年10月1日 · The removal of an N-methyl group, or N-demethylation, is a useful chemical transformation in organic synthesis which has particular importance in the field of alkaloid chemistry. Historically,...