Hydantoin, or glycolylurea, is a heterocyclic organic compound with the formula CH 2 C(O)NHC(O)NH. It is a colorless solid that arises from the reaction of glycolic acid and urea. It is an oxidized derivative of imidazolidine. In a more general sense, hydantoins can refer to groups or a class of compounds with the same ring structure as the ...

1985年1月1日 · H-NMR, IR, and UV techniques are widely used to study ionization and tautomerism in hydantoins. Hydantoins are weak acids which owe their acidic character to dissociation of the proton bonded to the 3-nitrogen atom as this allows for maximum delocalization of charge in anion.

Biocidal properties of the modified fibers could be demonstrated after a chlorination reaction by exposing the grafted fibers to a diluted chlorine solution, with which the grafted hydantoin rings were converted to N-halamine structures. The polymeric N-halamines could provide powerful and rapid antibacterial activities against E. coli and S ...

2021年2月2日 · Attack of the metallated urea leaving group on the nitrile generates a hydantoin that bridges the polycyclic products. X-ray crystallography reveals ring-dependant strain within the hydantoin.

The results of NMR spectroscopic and X-ray crystallographic studies are critically discussed with respect to the structure of hydantoins, their tautomerism, and their acidity. The imide NH proton of the preferred, nearly planar 2,4-imidazolidine-dione tautomer proved to be more acidic than the corresponding amide NH proton.

2023年8月15日 · Hydantoins are known to interact with electrophiles at the two N atoms and at carbon-5. Electrophilic C=O groups could be attacked by nucleophiles, resulting in ring hydrolysis. Furthermore, partial or absolute reduction of the C=O group could also occur.

Attack of the metallated urea leaving group on the nitrile generates a hydantoin that bridges the polycyclic products. X-ray crystallography reveals ring-dependant strain within the hydantoin. ourable cyclisations.

The molecular structure of 8r is characterized by a hydantoin nucleus, substituted at the two nitrogen atoms and at the C3 carbon. The hydantoin ring is planar, with a maximum deviation of 0.032(4) Å (C2) from the best mean plane.

The hydantoin ring is a useful centre in synthetic chemistry, especially for combinatorial chemistry, multicomponent reactions and in diversity-oriented synthesis. It is also found in pharmacologically active molecules, such as the anticonvulsant phenytoin.

2024年9月4日 · Hydantoin molecules form two chains linked by NÐH. O hydrogen bonds, from which inversion centres create a `chain of rings'. Out of 50 hydantoin moieties in 49 independent. the Cambridge Structural Database [Version 5.25; Allen (2002). Acta Cryst.