VPDs with very short coupling intervals developing during an acute stage of myocardial infarction would predict the development of early cycled reentry, potentially culminating in VF, and requires ...

BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...

BACKGROUND: Limited evidence exists on the prognostic role of continuing medical therapy in patients with heart failure (HF) and an ejection fraction (EF) that has improved over time. This study ...

Myocardial infarction (MI) elicits mitochondria reactive oxygen species (ROS) production and cardiomyocyte (CM) apoptosis. Nrf3 (nuclear factor erythroid 2-related factor 3) has an established role in ...

P2Y 12 inhibitor‐based single antiplatelet therapy (SAPT) after drug‐eluting stent implantation reduces major bleeding without increasing the risk of major adverse cardiovascular and cerebral events ...

Type 2 diabetes (T2D) is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). This study examined the interplay between watching television and T2D genetic risk for risk of ASCVD.

Despite insufficient evidence to support direct-to-consumer genetic testing in routine clinical care, cardiovascular clinicians increasingly face questions about its utility and interpretation because ...

Department of Neurology, Massachusetts General Hospital, Boston. (P.K., P.L.M.) Center for Genomic Medicine, Massachusetts General Hospital, Boston. (P.K., P.L.M ...

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Low-density lipoprotein (LDL) is internalized into cells mainly through LDLR (LDL receptor)–mediated endocytosis. In an acidic endosome, LDLR is released from LDL and recycles back to the cell surface ...