BACKGROUND: Viral cardiac infection represents a significant clinical challenge encompassing several etiological agents, disease stages, complex presentation, and a resulting lack of mechanistic ...

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Department of Preventive Medicine, Northwestern University Feinberg School of ...

Background— Pathological aspects of atherosclerosis are well described, but gene profiles during atherosclerotic plaque progression are largely unidentified. Methods and Results— Microarray analysis ...

Adrenergic signaling is downregulated in various cardiac diseases, a hallmark of heart failure (HF). In classic literature, the primary cardiac β 1 adrenergic receptor (β 1 AR) undergoes ...

Background—Exaggerated and prolonged inflammation after myocardial infarction (MI) accelerates left ventricular remodeling. Inflammatory pathways may present a therapeutic target to prevent post-MI h ...

BackgroundGrowth hormone–releasing hormone agonists (GHRH‐As) stimulate cardiac repair following myocardial infarction (MI) in rats through the activation of the GHRH signaling pathway within the hea ...

Abstract—Unstable angina is a critical phase of coronary heart disease with widely variable symptoms and prognosis. A decade ago, a classification of unstable angina based on clinical symptoms was in ...

Background— Atherosclerosis is a multifactorial disease in which inflammatory processes play an important role. Inflammation underlies lesion evolution at all stages, from establishment to plaque rup ...

Background—Prior studies have demonstrated low use of implantable cardioverter defibrillators (ICDs) as primary prevention, particularly among women and blacks. The degree to which the overall use of ...

Background— Whether adult cardiomyocytes have the capacity to regenerate in response to injury and, if so, to what extent are still issues of intense debate. In human heart failure, cardiomyocytes ha ...

The purpose of this study was to investigate a therapeutic approach targeting the inflammatory response and consequent remodeling from ischemic myocardial injury. Profiling of coronary thrombus ...

Introduction. The presence of coronary collaterals is a favorable prognostic factor in coronary artery disease, associated with reduced myocardial infarct size and increased patient survival. 1 ...