Background—Although frequently assessed in trials and clinical practice, hemodynamic response to therapy has never been validated as a surrogate end point for clinical events in pulmonary arterial hy ...

Background:Atherosclerotic plaque formation results from chronic inflammation and fibroproliferative remodeling in the vascular wall. We previously demonstrated that both human and mouse atherosclero ...

Background:Extracellular hemoglobin and cell-free heme are toxic breakdown products of hemolyzed erythrocytes. Mammals synthesize the scavenger proteins haptoglobin and hemopexin, which bind extracel ...

From the Department of Cardiovascular Medicine (M.I., H.M., S.M., T.I., T.K., A.T., K.S.) and Clinical Chemistry and Laboratory Medicine (D.K., N.H.), Graduate School ...

Originally published1 Feb 1982https://doi.org/10.1161/01.RES.50.2.175Circulation Research. 1982;50:175–191 ...

Background— In a recent cohort study, prolongation of the corrected QT interval (QTc) was associated with an independent increased risk of sudden cardiac death (SCD). We evaluated determinants of pro ...

Background— Although implantable cardioverter-defibrillator (ICD) therapy reduces mortality in moderately symptomatic heart failure patients with an ejection fraction ≤35%, many such patients do not ...

BackgroundPlatelet function is associated with adverse events in patients with cardiovascular disease (CVD). Methods and ResultsWe examined associations of baseline platelet function with incident CV ...

Background— Atherosclerotic plaque rupture, the most important cause of acute cardiovascular incidents, has been strongly associated with vascular inflammation. On the basis of the hypothesis that th ...

Background— Platelet-activating factor acetylhydrolase (PAF-AH), also denoted as lipoprotein-associated phospholipase A2, is a lipoprotein-bound enzyme that is possibly involved in inflammation and a ...

*Correspondence to: Jeffrey F. Scherrer, PhD, Family and Community Medicine, Saint Louis University School of Medicine, 1402 N. Grand Blvd, St. Louis, MO 63104. E ...

Background—In the presence of ST-elevation myocardial infarction, patients with successful epicardial reperfusion (TIMI 3 flow) but persistent ST elevation on a 12-lead ECG are at high risk for subse ...