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AbstractDiagnostic delays in patients with brain cancer are common and can impact patient outcome. Development of a blood-based assay for detection of brain cancers could accelerate brain cancer ...

AbstractPurpose:. The incidence of human papillomavirus (HPV)–associated head and neck squamous cell carcinoma (HPV + HNSCC) is increasing in the United States. Currently, there are no early detection ...

PGV001 neoantigen vaccine is safe and drives sustained antigen-targeted antibody responses, polyfunctional CD4+ and CD8+ T-cell immunity, and a diverse neoantigen-specific T-cell receptor repertoire ...

The authors show that TLR5 signaling is a host-intrinsic mechanism underlying immunotherapy failure against ovarian cancer because it disrupts DC–CD8+ T-cell interactions. Blocking TLR5 and PD-L1 and ...

Abstract. The complementarity and clinical utility of combining liquid biopsies and radiomic image analysis has not been demonstrated. ctDNA minimal residual disease after chemoradiotherapy (CRT) for ...

Cancer cells exhibit a characteristic metabolic pattern known as the Warburg effect, which upregulates glycolysis even in aerobic environments. As a result, cancer cells are exposed to an acidic ...

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Targeting KRAS in pancreatic cancer induces a resistant, highly differentiated cell state that serves as a reservoir for disease relapse, and cytoablative strategies aimed at this state offer a novel ...

AbstractPurpose:. Chimeric antigen receptor (CAR) T-cell therapy is a potent immunotherapy for hematologic malignancies, but patients can develop long-term adverse events, including second primary ...