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J Med Chem:新研究表明一系列基于衣康酸衍生物的前体药物有望治疗斑秃
衣康酸是一种天然存在的物质,通过与免疫系统相互作用而具有抗炎作用。然而,衣康酸的弱点是它不容易穿透细胞。Majer团队花了几年时间开发一种治疗秃头的药物,通过开发基于衣康酸衍生物的前体药物克服了这一障碍,其中前体药物是一种仅在体内转化为活性药物的化合物。
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