At the 2025 Bitcoin Conference in Las Vegas, U.S Senator Cynthia Lummis and CLO of Coinbase Paul Grewal discussed the market structure bill, stablecoin bill, future taxing system, bitcoin strategy ...

Tubulin polymerization is critical in mitosis process, which regulates uncontrolled cell divisions. Here, we report a new class of pyrene-pyrazole pharmacophore (PPP) for targeting microtubules.

Tubulin is a protein that plays a crucial role in the structure and function of cells. It is the main component of microtubules, which are long, hollow fibers that provide structural support, help ...

Introduction Microtubules. Microtubules are large polymers formed by repeats of α- and β-tubulin heterodimers. Tubulin heterodimers fold via a highly conserved and complex pathway involving chaperones ...

The overall structure of T. thermophila tubulin is similar to that of human (RMSD of 0.49 Å over the 751 Cα atoms of curved αβ‐tubulin, and RMSD of 0.77 Å over the 801 Cα atoms of straight αβ‐tubulin) ...

The amino acid residues and secondary structure elements of β‐tubulin were modeled manually using Coot to mimic the colchicine‐bound conformation of Tt Tubulin (Tt–TD1 c). CA4 was manually docked in ...

This study newly identified the PSD lattice backbone structure and provides a new PSD architecture model comprising a non-microtubule tubulin-based backbone structure and its associated proteins ...

This manuscript presents a cryo-EM structure of the tubulin tyrosine carboxypeptidase VASH1-SVBP bound to a microtubule, providing an explanation for its substrate specificity (microtubule vs soluble ...

As well as serving an essential role in the structure and basic operation of cells, tubulin has also been identified as a potential novel therapeutic approach for cancer treatment. Microtubules ...