为探究衰老细胞（SnCs）与腰痛（LBP）关系，研究人员用o-vanillin 和 RG-7112 治疗sparc?/? 小鼠，发现可缓解 LBP。 在人体衰老和受到外界细胞应激时，衰老细胞（SnCs）会在体内不断积累。这些细胞会呈现出衰老相关分泌表型（SASP），释放出各种炎性和退行性因子，进而引发多种与年龄相关的疾病。其中，腰痛（LBP）作为全球导致残疾的首要原因，给个人生活质量和医疗系统都带 ...

Scientists target senescent "zombie cells" with new drugs called senolytics, which may slow aging and prevent diseases like ...

A recent study published on January 31, 2024, in Nature Aging introduces a potential new drug that could help. Scientists believe this drug can remove harmful “zombie” cells from the liver and slow ...

与广谱senolytics不同，广谱senolytic不分青红皂白地杀死衰老细胞，这种新型senolytic（753b）可以选择性地清除损害器官（比如肝脏）的有害衰老细胞。

USC Dornsife researchers found that mifepristone, a drug already used for medical treatments, may extend lifespan by enhancing mitophagy, similar to rapamycin. If its effects on fruit flies translate ...

The drug candidate was tested in a cell culture and a mouse model for MASLD, showing more powerful effects compared to previous senolytics. It selectively targeted senescent liver cells ...

A small study suggests that a type of medication called senolytics may help improve brain function in older adults at risk of Alzheimer’s disease. The study, called STAMINA, tested two drugs—D ...

A new pilot study known as STAMINA (Senolytics To Alleviate Mobility Issues and Neurological Impairments in Aging), that focused on the effects of senolytic medications, Dasatinib and Quercetin (DQ), ...

A new pilot study known as STAMINA (Senolytics To Alleviate Mobility Issues and Neurological Impairments in Aging), that focused on the effects of senolytic medications, Dasatinib and Quercetin ...

More information: Courtney L. Millar et al, A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease, eBioMedicine (2025). DOI: 10.1016/j.ebiom ...

A new pilot study known as STAMINA (Senolytics To Alleviate Mobility Issues and Neurological Impairments in Aging), that focused on the effects of senolytic medications, Dasatinib and Quercetin ...

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