Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known ...

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His scientific history began in the 60s when he approached molecular biology with the study of tRNA in the bacterium Streptomyces fradiae (Trentalance and Amaldi, 1965) but it was consolidated during ...

"AlphaFold is now routinely used in many biology labs. NuFold would be an RNA version of AlphaFold. So, in a way, we're extending the breakthrough of AlphaFold into the world of RNA, which has ...

Representing the most referenced spatial biology technology in the industry, RNAscope provides an unprecedented single-cell view of disease pathology and therapeutic response across a wide range ...

Christopher Burge, the Uncas and Helen Whitaker Professor of Biology at MIT, is the senior author of the study, which appears today in Nature Communications. RNA splicing, a process discovered in ...