In contrast, as judged by the global size, this RNA undergoes structural collapse at Mg2+ concentrations much lower than required to drive folding of the RNA completely to the native state.

During transcription, the enzyme RNA polymerase (green) uses DNA as a template to produce a pre-mRNA transcript (pink).

This decision was informed by the comprehensive KARDIA Phase II programme, including KARDIA 1, KARDIA 2 and the most recent KARDIA-3 study evaluating the efficacy and safety of zilebesiran in patients ...