Here we show that pyrimidine nucleotides can also bind and inhibit its proton-conducting activity. All nucleotides bound in a pH-dependent manner, with the highest binding affinity observed for ATP, ...

School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Xiaolingwei 200, Nanjing 210094, P. R. China ...

The RNA Institute, University at Albany, State University of New York, Albany, New York 12222, United States Department of Biological Sciences, University at Albany, State University of New York, ...

CDK: cyclin-dependent kinase; IC 50: half maximal inhibitory concentration; Phospho-RNAPolyII: phosphorylated RNA polymerase II. *From the corresponding structures in Figure 6.

Despite great progress in delineation of molecular mechanisms underlying development of disease, standard therapy has not advanced at the same pace. The multifunctional signaling molecule Ca 2+ ...

In all characterized RNRs, the binding of effector dATP alters the active site to select for pyrimidines over purines, whereas effectors dGTP and TTP select for substrates ADP and GDP, respectively.