Cancer Discovery publishes high-impact articles featuring major advances in research and clinical trials. Topics span the spectrum of cancer research and medicine from the laboratory to the clinic to ...

Copyright 2025 The Associated Press. All Rights Reserved. Actor Gene Hackman arrives with his wife, Betsy Arakawa, for the 60th Annual Golden Globe Awards in Beverly ...

Department of Clinical Pharmacy and Pharmacy Administration, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, ...

According to a survey conducted by Intuit Credit Karma, 80% of Americans have seen a noticeable increase in the price of groceries in the last few years, especially after the pandemic. No matter ...

[48–50] Final data remain to be published. Table 1. Poly-(ADP-ribose) polymerase inhibitors in clinical studies. PARP inhibitor Number of completed or ongoing studies Type of studies completed ...

Molecular mechanism studies demonstrated that FMN had this effect because it could target the activation of the Nrf2 pathway, increase the activity of the phase II metabolizing enzyme glutathione ...

Over 1.3 crore people visited the Maha Kumbh on Monday itself. The Maha Kumbh Mela commenced on January 13. The month-long celebration of Maha Kumbh, one the world’s largest religious gatherings, ...

为探究 PARP 抑制剂耐药机制，研究人员针对 SETD1A 在相关癌细胞中的作用展开研究，发现其可致 ATM 及 BRCA1 缺陷细胞耐药，或为临床提供新方向。 在癌症治疗的战场上，PARP 抑制剂（PARPi）曾被寄予厚望。它就像一颗精准的 “智能炸弹”，专门瞄准那些在 DNA 双链 ...

Eikon’s EIK1003 selectively inhibits PARP1 with the goal of offering the same efficacy as currently available PARP inhibitors while avoiding the toxicity of those drugs. EIK1003 is in Phase 1 ...

Consistent evidence for PCSK9 (proprotein convertase subtilisin/kexin type 9), IL6R (interleukin‐6R), ECM1 (extracellular matrix protein 1), and ANGPTL4 (angiopoietin‐related protein 4 ... AAA ...