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MONOSAN-小鼠抗MDM2,克隆SMP14:细胞核染色与免疫组化优选
MDM2的表达本身是由p53诱导的,可能是p53在正常细胞周期中自我调节其活性的一种方式。然而,MDM2的过表达会导致p53调控的生长控制丧失,从而导致细胞增殖失控。此外,MDM2还可以结合视网膜母细胞瘤肿瘤抑制蛋白(Rb),并抑制其生长调控功能。MDM2通过结合 ...
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