Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug ...

In the context of atherosclerosis, TREM2 signaling promotes foam cell formation and is crucial for maintaining macrophage survival and plaque stability through efferocytosis and cholesterol efflux.

For example, NRP1 has been implicated in macrophage activation during sepsis and in promoting inflammation in obesity-related metabolic diseases. Similarly, NRP2’s pro-reparative roles in resolving ...

These monocyte-derived macrophages exhibited higher levels of CD36 expression and enhanced efferocytosis, a process that clears dead cells and promotes tissue repair. Further analysis revealed that ...

Males with pulmonary arterial hypertension (PAH) have more proinflammatory macrophages — a type of immune cell — in the lungs than do females with the disease, a study suggests. Researchers identified ...

如果是，它又是通过什么机制来影响的呢？为了弄清楚这些问题，解放军总医院的研究人员展开了深入的探索，并在《Cell Communication and Signaling》期刊上发表了题为 “Neutrophil extracellular traps impair macrophage efferocytosis via the PI3K/Rac1 pathway in diabetic ...

Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...