We review how these specific requirements are addressed by the existing cell culture systems for the generation of hiPSC-derived hepatocytes, describe their applications for modeling hepatic disorders ...

Researchers identify target to enhance NK cell function for liver cancer therapy in Korea New insights into immune cell dynamics could lead to innovative therapies for cancer in Korea.

This suggests these cells may be useful as new therapeutic targets for various liver conditions. The work appears in the journal Immunity. Macrophages are specialized immune cells located in every ...

As a metabolic center, the liver prevents inappropriate immune responses to abundant dietary antigens within the liver that could result in liver injury. This self-preservation mechanism can however ...

and occurs when excess fat builds up in liver cells. It can lead to inflammation, scarring (cirrhosis), and an increased risk of cancer and liver failure. "We think of air pollution as being ...

Lung cancer liver metastases are tumors that form in the liver from cancer cells that have broken away from the primary cancer and spread through the blood or lymphatic system. The liver is a common ...

People with cirrhosis are at an increased risk of liver cancer. Treatment may include surgery, a liver transplant, ablation therapy (a needle or probe is used to kill cancer cells), embolization ...

The liver is largely comprised of hepatocytes, but Kupffer cells, endothelial cells and hepatic stellate cells are also present. A perfusion-independent method to isolate ultrapure liver ...

Accumulation of fat within liver cells triggers a cascade of events ultimately leading to liver scarring. About 20% of people with MASH can progress to late-stage liver scarring which is called ...

The rest of the alcohol can damage and destroy liver cells. The liver is very good at regenerating itself. However, in people who regularly drink too much alcohol, the damaged liver cannot ...

A team led by UT Southwestern Medical Center researchers has identified a key mechanism responsible for endosomal recycling ...