Background: Variable rates of HER2 protein overexpression and gene amplification have been reported in advanced ovarian cancers (AOC). Trastuzumab, tested only as a single agent, has been shown to ...

The first patients have been enrolled in the HEROES trial, exploring de-escalation of anti-HER2 therapy in metastatic HER2+ breast cancer using circulating tumor DNA. The first patient with metastatic ...

Seagen is a specialist in antibody-drug conjugates, but has looked to Chinese biotech RemeGen for a HER2-targeting candidate that could challenge rival drugs from AstraZeneca/Daiichi Sankyo and Roche.

Dr. Debu Tripathy discussed the importance of understanding the distinctions between HER2-low and HER2-ultralow breast cancer. All patients with breast cancer who may be candidates for antibody-drug ...

Breast cancer classed as HER2-positive – defined as an immunohistochemical (IHC) score of three or more – accounts for somewhere between 20% to 25% of all patients with the disease.

When you have HER2-negative advanced (metastatic) breast cancer, treatment usually focuses on managing your disease, not curing the cancer. The goal is to help you live longer and have a better ...

The following is a summary of “HER2-low status as a distinct breast cancer subtype: myth or truth? Analysis of the WSG trials WSG-ADAPT-HR+/HER2-, WSG-PlanB, and WSG-ADAPT-TN,” published in the ...

Breast cancer is a heterogeneous malignancy that can be divided into several molecular subtypes according to estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 ...

为解决 HER2 阳性晚期乳腺癌治疗难题，复旦大学附属肿瘤医院等研究人员开展 ARX788 与拉帕替尼联合卡培他滨对比研究。结果显示 ARX788 显著延长 PFS，安全性可控。该研究为乳腺癌治疗提供新选择，值得科研读者一读。 在全球范围内，乳腺癌堪称女性健康的一大 ...

Credit: Shutterstock / Maria Sbytova. Pharma giant Pfizer and Arvinas’s human epidermal growth factor receptor 2 (HER2) negative breast cancer therapy, vepdegestrant, has seen mixed results after it ...

Tumors, such as some breast and ovarian cancers, can express the marker HER2. HER2 is responsible for cancer growth and is the target of existing therapies, such as the most commonly used type of ...