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Sanofi R&D, Industrial Park Hoechst, 65926 Frankfurt am Main, Germany ...

BH4 (tetrahydrobiopterin) strongly regulates this oxidation step as a cofactor, which is produced by guanosine triphosphate (GTP) by GTP cyclohydrolase (GPTCH). Then, aromatic amino acid decarboxylase ...

2021). Tetrahydrobiopterin (BH4), produced from guanosine triphosphate (GTP) through a process regulated by the rate-limiting enzyme GTP cyclohydrolase 1 (GCH1), possesses inherent antioxidant ...

Based upon a successful engagement with the US Food and Drug Administration (FDA) at the End-of-Phase 2 meeting in January ...

在体内，Crm1 与 NPC 稳定相互作用；在体外，Crm1 可直接与 Gcn4 和 Nup2 结合。重要的是，Crm1 与 Gcn4 的相互作用既不依赖于 Ran - 鸟苷三磷酸（Ran - guanosine triphosphate，Ran - GTP），也不依赖于核输出序列结合位点。最后，Crm1 和 Ran - GTP 可刺激 Gcn4 与 DNA 的结合 ...

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, Rome 00185, Italy ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Uncoupling protein 1 (UCP1, SLC25A7) is ...