Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth ...

Researchers developed novel genetic tools to trace, ablate, and manipulate p16^Ink4a+^ senescent cells, revealing their ...

This useful study reports that the exogenous expression of the microRNA miR-195 can partially compensate in early B cell development for the loss of EBF1, one of the key transcription factors in B ...

The molecular players that mediate gene repression in LADs are currently unknown. Here, we performed FACS-based whole-genome genetic screens in human cells using LAD-integrated fluorescent reporters ...

A landmark study has begun to unravel one of the fundamental mysteries in neuroscience -- how the human brain encodes and makes sense of the flow of time and experiences. A landmark study led by ...

Following their emergence, HSCs migrate to the fetal liver before ultimately colonizing the bone marrow (BM), which then becomes the predominant site of adult hematopoiesis (1). Adult HSCs primarily ...

While the innate immune sensing pathways cGAS-STING and RLR-MAVS impact the pathogenesis and therapeutics of malignant diseases, their effects on cell residency and motility remain incompletely ...

Harnessing the body's B-cells to fight tumors may be a promising treatment for glioblastoma, according to a Northwestern Medicine study recently published in the Journal of Clinical Investigation.

Another name for it is precursor lymphoblastic lymphoma. It usually is a tumor of the T cells but sometimes the cells are B cells, and those terms will be used in naming. A blast cell is an immature ...

Diffuse large B cell lymphoma (DLBCL) is a cancer that affects white blood cells called B cell lymphocytes. Ordinarily, these cells help protect against infection and disease. In DLBCL ...

Fetal aneuploidy refers to a condition where a fetus has an abnormal number of chromosomes in its cells. Typically, a human being has 46 chromosomes in each cell, arranged into 23 pairs.

Department of Pharmacology, University Medical Center, Johannes Gutenberg University, Mainz, Germany Recent evidence suggests that adaptive immune cells are important contributors to metabolic ...