Therein lies an opportunity to stop it, according to scientists led by Sarah Tabrizi of University College London. In the February 12 Science Translational Medicine, they reported that taking down ...

Huntington's disease is a genetic condition caused by an unusually long DNA sequence (CAG) in the huntingtin gene. In individuals with HD, this already extended sequence of CAGs continues to get ...

Evo 2 can predict and design the genetic code—DNA, RNA, and proteins—of all domains of life. The model has been trained on nearly 9 trillion nucleotides, the building blocks of DNA and RNA. “We make ...

The mixture was then incubated at 4°C for 24 h to precipitate pullulan. The precipitate was dissolved in deionized water at 80°C, followed by a repetitive ethanol precipitation procedure. The ...

We also show that the compounds are clickable with both a fluorescent probe as well as biotin, thus they can be visualized in cells, and their ability to induce crosslinks in genomic DNA can be ...

n in vertebrates – and sequence-specific DNA-binding proteins (Palm and de Lange, 2008). The telomere nucleoprotein complex has various pivotal functions such as protection of chromosome ends, ...

But three years ago, chemistry professor Floyd Romesberg of the Scripps Research Institute in California and colleagues extended this alphabet, reporting the creation of additional artificial ...

Here, we present a general framework (FeatureREDUCE) for building sequence-to-affinity models based on a biophysically interpretable and extensible model of protein-DNA interaction that can account ...