ERRα 促进 PCSCs 向 OXPHOS 的能量代谢转变：利用 Seahorse Extracellular Flux 分析仪检测发现，PCSCs 富集的前列腺球体相对于其贴壁亲本细胞，具有更高的氧消耗率（OCR）和 ATP 产生，同时细胞外酸化率（ECAR）降低，表明 PCSCs 更依赖 OXPHOS 供能。此外，ERRα 过表达增强了 ...

Background: A metabolic shift from fatty acid (FAO) to glucose oxidation (GO) occurs during cardiac hypertrophy (LVH) and heart failure with reduced ejection fraction (HFrEF), which is mediated by PGC ...

Here, we find that high STING impairs tumor cells growth by inhibiting both aerobic glycolysis and oxidative phosphorylation (OXPHOS) independently of its innate immune action. Knockout of STING in ...

TSC1, Tuberous Sclerosis Complex 1; PI3K, Phosphatidylinositide 3-kinase; AKT1, AKT serine/threonine kinase 1; GATOR1, GAP activity toward Rags 1; GDP, Guanosine diphosphate; PGC1α Peroxisome ...

Notably, we found that PA28γ enhances C1QBP protein stability in OSCC. Functionally, PA28γ contributes to the malignant progression of OSCC by affecting mitochondrial morphology and oxidative ...

Our results show 2 distinct HFpEF subgroups, 1 being more similar to controls. Overall, both analyses of the HFpEF proteome independently highlight defects in protein translation, mitochondrial ...

Sarcomas are generally classified into soft tissue sarcomas, such as fibrosarcoma, and bone sarcomas such as chondrosarcoma, which are rare cancers in adults accounting for about 1% of all cancer ...

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