Tendon stem cells differentiate into tenocytes (Zhang, 2010); the predominant cell type within tendon, responsible for producing extracellular matrix (ECM). The local stem cell environment (niche) is ...

A recent article in Small highlights a new method for studying tumor cell interactions and testing anti-metastatic drugs through the development of an Under-oil Open Microfluidic System (UOMS).

Organization of different cell types and the extracellular matrix (ECM ... interplay can lead to complications in tissue regeneration or to hypertrophy and cancer. We investigate how the composition ...

An international research team led by a Boston College professor has uncovered a drug and diet pairing that could fight a deadly brain cancer The international team combined a calorie-restricted diet ...

In addition, he studies the spindle assembly checkpoint which ensures proper chromosome segregation and is often deregulated in cancer. Joan Massagué, PhD Joan Massagué studies the control of stem ...

Organoids contain multiple organ-specific cell types ... other and ECM proteins, thereby mimicking the functionality and structure of organs in vivo. This allows researchers to model organ-specific ...

The numerous cells that make up mammalian tissues are surrounded by an intricate network of proteins known as the extracellular matrix (ECM). Together, these proteins provide cells with a structural ...

Our laboratory aims at exploiting recent advances in stem cell biology to develop radically new therapies for degenerative disease and cancer. The main focus in the lab is on the biology and ...

Cancer research has long relied on ... and preserve essential cell-cell and cell-extracellular matrix (ECM) interactions. They offer a promising platform for studying disease progression, drug ...

The STaR Center's 30 associated investigator study adult and embryonic stem cells, as well as the role of cancer stem cells in contributing to relapse. We are interested in fundamental questions, such ...