资讯

C&EN28 天
Design of Inhibitors of Orotidine Monophosphate Decarboxylase Using Bioisosteric ...
Inhibitors of orotidine monophosphate decarboxylase (ODCase) have applications in RNA viral, parasitic, and other infectious diseases. ODCase catalyzes the decarboxylation of orotidine monophosphate ...
C&EN29 天
Probing Binding Requirements of Type I and Type II Isoforms of Inosine Monophosphate ...
Novel tiazofurin adenine dinucleotide (TAD) analogues 25−33 containing a substituent at C2 of the adenine ring have been synthesized as inhibitors of the two isoforms of human IMP-dehydrogenase. The 2 ...