New research suggests that specific changes in blood composition may help protect the brain and reduce the risk of developing ...

More than half of patients with chronic lymphocytic leukemia (CLL) harbor clonal hematopoiesis (CH) mutations, which are linked to increased neutropenia risk and Richter transformation (RT), according ...

A study published in Cell Stem Cell reveals that some mutations in blood stem cells might help protect against late-onset ...

A study published in Cell Stem Cell reveals that some mutations in blood stem cells might help protect against late-onset ...

Among clonal hematopoiesis variants concordantly detected at baseline and progression on 177 Lu-PSMA-617, the median variant allele frequency change for mutations in DNA damage repair genes was higher ...

这项里程碑式的研究，为我们描绘了化疗对正常血细胞造成的长期、深刻且复杂的伤害。它告诉我们，化疗的代价，远不止于那些我们能看到或感受到的短期副作用。在基因组的层面上，它留下的伤痕可能会伴随患者的一生。

如果说以上发现是对生命奥秘的探索，那么接下来，这项研究则向我们展示了其转化为临床应用的巨大潜力。研究的核心目标之一，就是利用这幅健康的“生命蓝图”作为标尺，去识别和诊断疾病，特别是骨髓增生异常综合征（Myelodysplastic Syndrome, ...

Haematopoietic stem cells articles from across Nature Portfolio Haematopoietic stem cells are progenitor cells that have the ability to both generate all types of blood cells, including those of ...

Clonal hematopoiesis of cells carrying an ASXL1 mutation promotes atherosclerosis. An unexpected function of ASXL1 — direct inhibition of IL-1 receptor and Toll-like receptor signaling — was ...