Department of Chemistry, The University of Hong Kong, Kowloon, Hong Kong 999077, China HKU-CAS Joint Laboratory on New Materials and Department of Chemistry, The University of Hong Kong, Kowloon, Hong ...

Cell and gene therapies (CGTs) represent the cutting edge of drug discovery. 1 These are amongst the most advanced medical treatments, specifically designed to correct the root genetic cause of an ...

In contrast to organelles with a lipid bilayer membrane, membraneless structures are formed through a process known as liquid-liquid phase separation. When it comes to how and why cells create and use ...

Organelles can either be constructed de novo, or be remodelled and then segregated into the daughter cells. These are not necessarily mutually exclusive options. Organelle structure is controlled ...

For Piet Borst, a physician-biochemist and molecular biologist at the Netherlands Cancer Institute, success in science is a matter of luck. He described his career using the words “luck” and “accident ...

Hair cells are heterogenous, enabling varied roles in sensory systems. An emerging hypothesis is that the transmembrane channel-like (Tmc) proteins of the hair cell’s mechanotransduction apparatus ...

Regulation of stem cell fate is best understood at the level of gene and protein regulatory networks, though it is now clear that multiple cellular organelles also have critical impacts. A growing ...

Neuronal cell morphogenesis depends on proper regulation of microtubule-based transport ... Furthermore, MAP7 recruits kinesin-1 dynamically to microtubules, leading to alterations in organelle ...

The spatial organization of RNA within cells is a crucial factor influencing a wide range of biological functions ... We demonstrate that APEX-RIP is able to enrich endogenous RNAs in ...