However, it is envisioned that our CRISPR-Cas12a based detection system, when combined with a pre-amplification strategy, may confer higher detection sensitivity. Also, our detection platform may need ...

Amgen R&D Postdoctoral Fellows Program, Thousand Oaks, California 91320, United States Large Molecule Discovery & Research Data Science, Amgen Research, Thousand Oaks, California 91320, United States ...

Using gene editing with CRISPR-Cas9, the team has been able to study these proteins without altering ... Dec. 13, 2024 — Microorganisms produce a wide variety of natural products that can be ...

We also mentioned how important information can be discovered by CRISPR screening approach and there are a lot to do the efficiently optimize this method to be used in NK cells and T cells. Overall, ...

Get Instant Summarized Text (Gist) An enhanced CRISPR tool, CRISPR-Cas12a, has been developed to enable simultaneous assessment of multiple genetic changes, improving disease modeling and gene editing ...

Apr. 29, 2021 — Researchers have developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility ...

Exploration of dsRNA interactome using the K1 antibody and functional studies using CRISPR-Cas9 knockout screening of these dsRBP candidates elucidate the role of dsRNA interactome in immune ...

To that point, Xu says, further work in “strategic protein design and engineering, effective screening ... and CRISPR-Cas to knock out particular genes. That could result in new plant cell ...

CRISPR-Cas9 技术的出现，为科学家们提供了强大的基因编辑工具，通过 Pooled loss-of-function screening，能大规模探究基因功能，在研究细胞生长、药物抗性和病毒感染等方面成果显著。将其与单细胞 RNA 测序（scRNA-seq）结合后，可在同一细胞中实现基因抑制与转录组 ...