Cell Death & Differentiation - BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists Skip to main content Thank you for visiting nature.com.

It has been over 30 years since the original discovery of BCL2 and its role as an arbiter of prosurvival function. 5,6 Apoptosis is controlled via a series of pro-apoptotic and anti-apoptotic proteins ...

Molecular discovery suggests new strategy to fight ... MCL-1's own BH3 death domain helix is a uniquely exclusive MCL-1 inhibitor that resensitizes cancer cells to select apoptotic stimuli ...

Scientists in Australia have discovered a key molecule needed to kill the blood vessels that supply tumors. The research team found that for anti-cancer therapies that target tumor blood vessels ...