Given that the autophagy pathways also play an important role in the clearance of misfolded and aggregated proteins, enhancing the autophagy pathways could be of therapeutic importance in TDP-43 ...

New research from the Regulatory RNA and Chromatin lab at the Josep Carreras Institute sheds light on one of these alterations: autophagy malfunction. The inner life of a cell is highly dynamic ...

This month's cover highlights the article RudLOV is an optically synchronized cargo transport method revealing unexpected effects of dynasore by Akiko K. Satoh, Takunori Satoh and colleagues. The ...

Children with autism spectrum disorders (ASDs) often display atypical learning styles; however, little is known regarding learning-related brain plasticity and its relation to clinical phenotypic ...

This work was supported by grants from the National Natural Science Foundation of China (91854201), the Research Grants Council of Hong Kong (AoE/M-05/12, CUHK 14100818, 14101219, C4033-19E, C4002-17G ...

Autophagy is a highly conserved lysosomal degradation system that involves the creation of autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins and damaged organelles ...

Cellular and molecular mechanisms of cancer dormancy are not fully understood. Recent studies indicate that a major cellular stress response mechanism, autophagy, plays an important role in the ...

Most of these cellular changes were not captured by mRNA profiling, and included activation of ubiquitin-mediated autophagy, an evolutionarily ancient cellular antimicrobial system. This analysis also ...

If you think about it, Portal have already done more than they’ve ever had to do. They solidified what they’re best at with Outré, and they could have reproduced slight variations on that album over ...