This Research Topic is the second volume of the “Adenosine Pathways in Cancer Immunity and Immunotherapy” Community Series. Please see Volume I here. The durable responses seen using Immune checkpoint ...

In this article, Nedbalova et al. investigate the biochemical pathway that acts in circulating immune cells to generate adenosine, a systemic signal that directs nutrients toward the immune response, ...

Convincing data supports this idea. The authors use metabolic tracing approaches to identify the biochemical pathways that contribute to the regulation of adenosine levels and the S-adenosylmethionine ...

Numerous studies have shown the potential and viability of immune responses against leukemia. In the classical pathway, this process is often initiated by the upstream activity of CD39, which ...

Adenosine is an important chemical known as a nucleoside that exists naturally in all cells of the body. It is used to transfer energy within the cells by forming molecules like adenosine triphosphate ...

The adenosine pathway has emerged as an attractive target for immuno-oncology R&D because it is thought to reduce the activity of misfunctioning regulatory T-cells that inhibit the immune response ...

Cellular Pathway of Methotrexate MTX affects enzymes in several important pathways, such as the folate and adenosine pathways involved in purine and pyrimidine metabolism within the cell.

A U of A researcher recently created a new class of drugs that targets and kills cancer cells with less damage to healthy ...