Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...

A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce new blood cells, according ...

This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the ...

A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce ...

25 in Nature Immunology, found that a DNA transcription-regulating protein called FLI-1 has a critical role in this ... using an approach similar to that of modified mRNA-based vaccines. "The stem ...

A recent study has uncovered the pivotal role of the transcription factor SOX9 in the development of hypospadias, a common ...

The company is currently developing a range of mRNA cancer therapeutics, including cancer and immunomodulatory cancer vaccines. Credit: KomootP / Shutterstock. Everest Medicines has dosed the first ...

The first patient has been dosed with EVM16 at Peking University Cancer Hospital, marking a major milestone as Everest’s proprietary AI-based tumor neoantigen prediction algorithm and clinically ...

Mature α-cells are characterized by the expression of transcription factors including Aristaless-related homeobox (Arx) (30), and MafB (31, 32). While β-cells express a distinct set of transcription ...

Vaccine manufacturers would have to waive indemnity from lawsuits for injuries stemming from vaccines under a bill advancing in the Iowa Senate. Sen. Doug Campbell, R-Mason City, at a subcommittee ...

Iowa lawmakers advanced a bill Monday banning the administration of mRNA vaccines. The bill, Senate File 360, would outlaw any person in the state of Iowa from administering an mRNA and would impose ...

Recapitulating the range of synchronizing frequencies required, non-intuitively, a less robust oscillator. We showed that p53 phase resetting altered the expression of downstream targets responsible ...