“Larger mRNA-based therapeutics are synthesised by in vitro transcription, which is not amenable to extensive nucleotide modifications and thus have poor stability when administered into the bod ...

LncRNAs and circRNAs are key regulators of gene expression, influencing disease mechanisms and offering potential as ...

A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce ...

A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce ...

CureVac and partner GSK are, meanwhile, also developing an mRNA-based flu vaccine, but are a little further back in development, as their shot is in phase 1 testing.

This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the ...

免疫原性测试是验证研究成果的重要环节。研究人员将克隆 A7、B2 与不同 HLA 类型的外周血单个核细胞（PBMC）进行共培养实验。结果发现，与未编辑的 YiP3 细胞相比，克隆 A7 能够显著降低效应记忆 T 细胞（effector memory T cell，TEM）和中枢记忆 T 细胞（central memory T cells，TCM）的增殖，同时也能明显降低自然杀伤细胞（natural ...

A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce ...

Activation of nuclear factor kappa B (NFκB), which is involved in their gene transcription, is increased in the intestinal mucosa of CD patients ... were cultured with or without butyrate for ...

针对DNA损伤的反馈网络是一个特别有趣的系统，它与癌症的形成有关。当细胞的DNA受损时，修复系统就会启动。但修复系统无法保证工作结果的正确，它们可能会出错，而这些错误将导致威胁整个生物体的癌变。为了避免这种危险，让生物体健康存活下去，受到潜在危险突变 ...