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痛风对结直肠癌的保护作用:孟德尔随机化研究揭示潜在抗癌新机制
在讨论部分,研究人员深入探讨了痛风对 CRC 产生保护作用的潜在机制。一方面,尿酸作为人体内的一种代谢产物,具有抗氧化特性,能够清除自由基,减少氧化应激对细胞 DNA 的损伤,从而维持基因组的稳定性,降低癌症发生的风险。另一方面,尿酸还可以激活人体的先天性免疫和适应性免疫,增强巨噬细胞的吞噬能力,使肿瘤细胞对自然杀伤细胞(NK ...
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