Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, California 91010, United States Irell and Manella Graduate School of Biosciences, City of ...

1 Department of Chemistry, Masaryk University, Brno, Czechia 2 International Clinical Research Center, St. Anne’s University Hospital, Brno, Czechia Homeodomain-interacting protein kinases (HIPKs) ...

including protein kinase pathways such as c-Jun N-terminal kinases (JNK), protein kinase B (PKB or Akt), and 5′ adenosine monophosphate-activated protein kinase (AMPK) (17). Curcuminoids exhibit a ...

Here, we report a crystal structure of the pleckstrin homology (PH) domain of Sec3 in complex with a nearly full-length version of Sso2 lacking only its C-terminal transmembrane helix. The structure ...

The mechanisms regulating synapse numbers during development and ageing are essential for normal brain function and closely linked to brain disorders including dementias. Using Drosophila, we ...