Ribosomes are the sites in a cell in which protein synthesis takes place. Cells have many ribosomes, and the exact number depends on how active a particular cell is in synthesizing proteins.

During translation, multiple ribosomes travel along the nucleic acid chain to build polypeptides that become functional proteins. Occasionally, these molecular decoders pause on the mRNA, either ...

We showed that non-AUG translation is strikingly resistant to multiple protein synthesis inhibitors, including cycloheximide. We find that these inhibitors slow elongating ribosomes, thereby inducing ...

The catalytic center of the ribosome, known as the peptidyl transferase center (PTC), is composed entirely of rRNA. The PTC is highly conserved across all domains of life, highlighting the fundamental ...

We call this a complementary copy. The newly formed strand of mRNA is now ready to leave the nucleus and travel to the ribosome. After translation, the polypeptide is finally folded into the ...

This film creatively illustrates the process of protein synthesis through dance, symbolizing the assembly of amino acids into proteins. It explains how genes encode instructions for amino acid ...

However, one significant challenge with circular mRNAs has been the inefficiency of their translation inside living organisms. Previous methods relied on long internal ribosome entry sites (IRES) for ...