A type of aggressive, treatment-resistant brain tumor has a distinct population of immune cells that support its growth, ...

Tumor suppressor genes act as “brakes” to stop cells before they can travel down the road to cancer. A loss of function mutation in these genes can be disastrous. Like all genes, tumor ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

Researchers pinpointed a specific mutation in the TLR7 gene ... to find effective treatments for lupus, and the ...

"We often assume that mutations in cancer genes are bad news ... This result was shocking since CDKN2A, a well-known tumor suppressor gene, typically plays a crucial role in preventing cancer ...

Monoallelic loss of PTEN and ARID1A is identified in normal colonic epithelium. The resulting haploinsufficient phenotypes ...